Human hair-follicle associated pluripotent (hHAP) stem cells differentiate to cardiac-muscle cells

Establishment of human hair follicle mesenchymal stem cells with overexpressed human hepatocyte growth factor

Objective(s): Chronic liver disease has become a major health problem that causes serious damage to human health. Since the existing treatment effect was not ideal, we need to seek new treatment methods. Materials and Methods: We utilized the gene recombination technology to obtain the human hair mesenchymal stem cells which overexpression of human hepatocyte growth factor (hHGF). Furthermore, ...

Stem Cells of Human Hair Follicles Can Differentiate Into Neurons: Region-Specific Multipotency of Human Hair Follicle Stem Cells

Hair follicle stem cells in the hair follicle bulge area of mice are nestinand CD34-positive, and keratin 15 (K15)negative. The mouse hair follicle stem cells are multipotent and can differentiate into neurons, glial cells, keratinocytes, smooth muscle cells, and melanocytes (Proc. Natl. Acad. Sci. USA 102, 5530-5534, 2005). Recently, pluripotent stem cells have been identified in human hair fo...

Pluripotent neural crest stem cells in the adult hair follicle.

We report the presence of pluripotent neural crest stem cells in the adult mammalian hair follicle. Numerous neural crest cells reside in the outer root sheath from the bulge to the matrix at the base of the follicle. Bulge explants from adult mouse whisker follicles yield migratory neural crest cells, which in clonal culture form colonies consisting of over a thousand cells. Clones contain neu...

Contractile smooth muscle cells derived from hair-follicle stem cells.

AIMS We hypothesized that hair-follicle stem cells can differentiate toward smooth contractile muscle cells, providing an autologous cell source for cardiovascular tissue regeneration. METHODS AND RESULTS Smooth muscle progenitor cells (SMPCs) were obtained from ovine hair follicles using a tissue-specific promoter and fluorescence-activated cell sorting. Hair-follicle smooth muscle progenito...

SnapShot: Hair Follicle Stem Cells